Article
Warfarin dose requirements with different genotypes of CYP2C9 and VKORC1 for patients with atrial fibrillation and valve replacement.
International journal of clinical pharmacology and therapeutics - 1 Feb 2017
Chen Weirong, Wu Luhua, Liu Xin, Shen Yue, Liang Yan, Zhu Jun, Tan Huiqiong, Yang Yanmin, Liu Qun, Wang Mingsheng, Liu Lisheng, Wang Xingyu
Abstract excerpt
AIMS: To investigate whether genetic variants of CYP2C9 and VKORC1 have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment with stable daily warfarin doses for a period of at least 3 months. METHODS: DNA was isolated and genotyped using a Warfarin dosage Prediction Kit for single nucleotide polymorphisms (SNPs) of...
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