Article
CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement.
British journal of clinical pharmacology - 1 Aug 2010
Cen Han-Jing, Zeng Wu-Tao, Leng Xiu-Yu, Huang Min, Chen Xiao, Li Jia-Li, Huang Zhi-Ying, Bi Hui-Chang, Wang Xue-Ding, He Yan-Ling, He Fan, Zhou Rui-Na, Zheng Qi-Shan, Zhao Li-Zi
Abstract excerpt
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Genetic polymorphisms of VKORC1 and CYP2C9 are known to influence warfarin dosage. * Recent studies among Caucasians showed that polymorphisms of CYP4F2 also play a role in warfarin pharmacogenetics. * The contribution of CYP4F2 variants to the variabili...
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