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Article

The effects of CYP2C9 and VKORC1 gene polymorphisms on warfarin maintenance dose in Turkish cardiac patients.

Future cardiology - 1 Nov 2020

Akdeniz Cansu Selcan, Cevik Mehtap, Canbolat Ismail Polat, Yurdakul Selen, Cagatay Penbe, Ciftci Cavlan, Karaalp Atila, Susleyici Belgin

Abstract excerpt

Aim: Our aim was to examine the effect of CYP2C9 and VKORC1 polymorphisms on warfarin dose requirements in Turkish patients. Materials & methods: 24 warfarin prescribed patients were included and analyzed for eight VKORC1 and 6 CYP2C9 polymorphisms in the study. Results: Patients with CYP2C9 *1/*1 and VKORC1 -1639 GG and GA genotypes required higher warfarin doses in comparison to wild type VKORC1 genotype....

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Identifiers

PMID: 32583677
DOI: 10.2217/fca-2020-0027

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