Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VKORC1 -1639G/A and 1173 C/T Genetic Polymorphisms Influence Individual Differences in Warfarin Maintenance Dose.

Genetic testing and molecular biomarkers - 1 Sept 2015

Li Yi, Zhu Jun, Ding Jianqiang

Abstract excerpt

OBJECTIVE: In this study, we investigated two VKORC1 gene polymorphisms, -1639G/A and 1173C/T, for effects on warfarin maintenance dosage in valvular heart disease (VHD) patients after cardiac valve replacement (CVR). METHODS: A total of 219 VHD patients receiving warfarin therapy after CVR surgery were recruited to this study between June 2010 and December 2013. Basic clinical data, prothrombin time, warfarin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Heart Valve Diseases
Share to Heart Valves

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxybutyrates

Share to Individuality

Share to Maintenance Chemotherapy

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 26167638
DOI: 10.1089/gtmb.2015.0097

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VKORC1 -1639G/A and 1173 C/T Genetic Polymorphisms Influence Individual Differences in Warfarin Maintenance Dose.PMID 26167638Read ↗

Impact of VKORC1 gene polymorphisms on warfarin maintenance dosage: A novel systematic review and meta-analysis of 53 studies.Semantic proximity Read ↗

Warfarin dose requirements with different genotypes of CYP2C9 and VKORC1 for patients with atrial fibrillation and valve replacement.Semantic proximity Read ↗

Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients.Semantic proximity Read ↗

VKORC1 gene polymorphisms and adverse events in Croatian patients on warfarin therapy.Semantic proximity Read ↗

A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.Semantic proximity Read ↗

Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients.Semantic proximity Read ↗

Frequency of VKORC1 (C1173T) and CYP2C9 genetic polymorphisms in Egyptians and their influence on warfarin maintenance dose: proposal for a new dosing regimen.Semantic proximity Read ↗

Integrated analysis of clinical and genetic factors on the interindividual variation of warfarin anticoagulation efficacy in clinical practice.Semantic proximity Read ↗

Prevalence of VKORC1 and CYP2C9 gene polymorphisms in Indian population and its effect on warfarin response.Semantic proximity Read ↗

Development and Validation of a Novel Warfarin Dosing Algorithm for Korean Patients With VKORC1 1173C.Semantic proximity Read ↗

Association of VKORC1 and CYP2C9 gene polymorphisms with warfarin dose requirements in a representative Iranian population with cardiac valve replacement surgery.Semantic proximity Read ↗

Impact of VKORC1, CYP2C9, CYP1A2, UGT1A1, and GGCX polymorphisms on warfarin maintenance dose: Exploring a new algorithm in South Chinese patients accept mechanical heart valve replacement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.