Article
Impact of VKORC1, CYP2C9, CYP1A2, UGT1A1, and GGCX polymorphisms on warfarin maintenance dose: Exploring a new algorithm in South Chinese patients accept mechanical heart valve replacement.
Medicine - 22 Jul 2022
Li Jin, Chen Tao, Jie Fangfang, Xiang Haiyan, Huang Li, Jiang Hongfa, Lu Fei, Zhu Shuqiang, Wu Lidong, Tang Yanhua
Abstract excerpt
BACKGROUND: Warfarin is the most recommended oral anticoagulant after artificial mechanical valve replacement therapy. However, the narrow therapeutic window and varying safety and efficacy in individuals make dose determination difficult. It may cause adverse events such as hemorrhage or thromboembolism. Therefore, advanced algorithms are urgently required for the use of warfarin. OBJECTIVE: To establish a...
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