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Article

Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients.

Pharmacogenetics and genomics - 1 Mar 2012

Zhong Shi-Long, Yu Xi-Yong, Liu Yuan, Xu Dan, Mai Li-Ping, Tan Hong-Hong, Lin Qiu-Xiong, Yang Min, Lin Shu-Guang

Abstract excerpt

OBJECTIVE: Compared with genetic factors, drug interactions are largely unexplored in pharmacogenetic studies. This study sought to systematically investigate the effects of VKORC1, STX4A, CYP2C9, CYP4F2, CYP3A4, and GGCX gene polymorphisms and interacting drugs on warfarin maintenance dose. METHODS: A retrospective study of 845 Chinese patients after heart valve replacement receiving long-term warfarin...

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Source

Identifiers

PMID: 22198820
DOI: 10.1097/FPC.0b013e32834f45f9

Genes

VKORC1
GGCX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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