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Article

Association of VKORC1 and CYP2C9 gene polymorphisms with warfarin dose requirements in a representative Iranian population with cardiac valve replacement surgery.

Pharmacogenetics and genomics - 1 Sept 2025

Maleki Omid, Gharechahi Javad

Abstract excerpt

BACKGROUND: Warfarin is a commonly used oral anticoagulant for managing thromboembolic events after cardiac valve surgery. However, its optimal dose varies between individuals, often requiring trial and error to determine. This study aimed to investigate the association of polymorphisms in the CYP2C9 and VKORC1 genes with warfarin dose requirements in an Iranian population undergoing cardiac valve replacement....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Heart Valve Prosthesis Implantation

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Source

Identifiers

PMID: 40511772
DOI: 10.1097/FPC.0000000000000571

Genes

CYP2C9
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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