Article
Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses.
Neurobiology of aging - 1 Sept 2021
Dilliott Allison A, Sunderland Kelly M, McLaughlin Paula M, Roberts Angela C, Evans Emily C, Abrahao Agessandro, Binns Malcolm A, Black Sandra E, Borrie Michael, Casaubon Leanne K, Dowlatshahi Dar, Finger Elizabeth, Fischer Corinne E, Frank Andrew, Freedman Morris, Grimes David, Hassan Ayman, Jog Mandar, Kumar Sanjeev, Kwan Donna, Lang Anthony E, Mandzia Jennifer, Marras Connie, Masellis Mario, McIntyre Adam D, Pasternak Stephen, Pollock Bruce G, Rajji Tarek K, Robinson John F, Rogaeva Ekaterina, Sahlas Demetrios J, Saposnik Gustavo, Sato Christine, Seitz Dallas, Shoesmith Christen, Steeves Thomas, Strother Stephen C, Swartz Richard H, Tan Brian, Tang-Wai David, Tartaglia Maria C, Troyer Angela K, Turnbull John, Zinman Lorne, Hegele Robert A
Abstract excerpt
For many years there has been uncertainty regarding how apolipoprotein E (APOE) E2 and E4 variants may influence overlapping features of neurodegeneration, such as cognitive impairment. We aimed to identify whether the APOE variants are associated with cognitive function across various neurodegenerative and cerebrovascular diagnoses (n = 513). Utilizing a comprehensive neuropsychology battery, multivariate...
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