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Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging

21 Feb 2023

Abstract excerpt

Apolipoprotein E (APOE) ε4, the strongest genetic risk factor for late onset Alzheimer's disease (LOAD), has been associated with cognitive decline independent from AD pathology, but the role for other LOAD risk genes in normal cognitive aging is less studied. We examined the effect of APOE ε4 and several different polygenic risk scores (PRS) for LOAD on cognitive level and decline in aging, using longitudinal...

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PMID: 36965205
DOI: 10.1016/j.neurobiolaging.2023.02.006

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