Article

Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride is a Safe and Effective Antithrombotic Therapy

2020-04-27

Abstract excerpt

<h4>Rationale</h4> Most of the current anti-platelet drugs inhibit platelet function permanently and have systemic side effects, including thrombocytopenia and hemorrhage. We previously found that thymidine phosphorylase (TYMP), a platelet cytoplasmic protein, facilitates multiple agonist induced platelet activation and enhances thrombosis. A specific TYMP inhibitor, namely, tipiracil hydrochloride (TPI), has bee...

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Literature Corpus work: 0f2c5943-e040-51be-855d-100bd192448b
DOI: 10.1101/2020.04.25.061234

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