Article
Exacerbation of thromboinflammation by JAK2V617F mutation worsens the prognosis of cerebral venous sinus thrombosis.
Blood advances - 25 Jun 2024
Bourrienne Marie-Charlotte, Le Cam Duchez Véronique, Faille Dorothée, Farkh Carine, Solo Nomenjanahary Mialitiana, Gay Juliette, Loyau Stéphane, Journé Clément, Dupont Sébastien, Ollivier Véronique, Villeval Jean-Luc, Plo Isabelle, Edmond Valérie, Jandrot-Perrus Martine, Labrouche-Colomer Sylvie, Cassinat Bruno, Verger Emmanuelle, Desilles Jean-Philippe, Ho-Tin-Noé Benoît, Triquenot Bagan Aude, Mazighi Mikaël, Ajzenberg Nadine
Abstract excerpt
ABSTRACT: Cerebral venous sinus thrombosis (CVST) is an uncommon venous thromboembolic event accounting for <1% of strokes resulting in brain parenchymal injuries. JAK2V617F mutation, the most frequent driving mutation of myeloproliferative neoplasms, has been reported to be associated with worse clinical outcomes in patients with CVST. We investigated whether hematopoietic JAK2V617F expression predisposes to...
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