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Article

Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.

Journal of the American Heart Association - 3 Jul 2017

Ren Meiping, Li Rong, Chen Ni, Pang Ningbo, Li Yongjie, Deng Xin, Wang Liqun, Luo Mao, Liu Yan, Hao Haiyan, Liu Yong, Sun Hongmin, Wu Jianbo

Abstract excerpt

BACKGROUND: Coagulation factor V (FV) plays a key role in hemostasis, is present in plasma and platelets, and has both pro- and anticoagulant properties; however, the contribution of platelet-derived FV to arterial thrombosis remains undetermined. METHODS AND RESULTS: Using transgenic mice with various levels of FV gene expression that was restricted to the plasma or platelets, the roles of platelet FV were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28673898
DOI: 10.1161/JAHA.117.006345
PMCID: PMC5586322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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