Article
Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets.
Blood - 15 Apr 1999
Law D A, Nannizzi-Alaimo L, Ministri K, Hughes P E, Forsyth J, Turner M, Shattil S J, Ginsberg M H, Tybulewicz V L, Phillips D R
Abstract excerpt
Agonists induce inside-out alphaIIbbeta3 signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in further platelet stimulation. Because the Syk tyrosine kinase is activated during both phases of integrin signaling, we evaluated its role in alphaIIbbeta3 function in murine platelets rendered null for Syk by gene targeting and in human platelets...
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