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Article

Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.

Archives of biochemistry and biophysics - 1 Apr 2017

Hu Meng-Jun, Wei Dian, Shao Xiao-Xia, Wang Jia-Hui, Liu Ya-Li, Xu Zeng-Guang, Guo Zhan-Yun

Abstract excerpt

Insulin-like peptide 5 (INSL5) is a gut peptide hormone belonging to the insulin/relaxin superfamily. It is implicated in the regulation of food intake and glucose homeostasis by activating relaxin family peptide receptor 4 (RXFP4). Previous studies have suggested that the B-chain is important for INSL5 activity against RXFP4. However, functionalities of the B-chain residues have not yet been systematically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28274616
DOI: 10.1016/j.abb.2017.03.001

Genes

INSL5
RXFP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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