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Article

Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor.

The Journal of biological chemistry - 2 Jan 2015

Huang Jianyun, Sun Yutong, Zhang J Jillian, Huang Xin-Yun

Abstract excerpt

G protein-coupled receptors (GPCRs) relay extracellular signals mainly to heterotrimeric G-proteins (Gαβγ) and they are the most successful drug targets. The mechanisms of G-protein activation by GPCRs are not well understood. Previous studies have revealed a signal relay route from a GPCR via the C-terminal α5-helix of Gα to the guanine nucleotide-binding pocket. Recent structural and biophysical studies uncover...

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Identifiers

PMID: 25414258
DOI: 10.1074/jbc.M114.608661
PMCID: PMC4281731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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