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Article

Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs.

The Journal of biological chemistry - 14 Nov 2008

Park Jae-Il, Semyonov Jenia, Yi Wei, Chang Chia Lin, Hsu Sheau Yu Teddy

Abstract excerpt

Relaxin peptides are important hormones for the regulation of reproductive tissue remodeling and the renal cardiovascular system during pregnancy. Recent studies demonstrated that two of the seven human relaxin family peptides, relaxin H2 (RLN2) and INSL3, signal exclusively through leucine-rich repeat-containing G protein-coupled receptors, LGR7 and LGR8. Although it was well characterized that an RXXXRXXI motif...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, G-Protein-Coupled

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Share to Sequence Homology, Amino Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 18772127
DOI: 10.1074/jbc.M806817200
PMCID: PMC2581550

Genes

RLN2
INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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