Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.

doi:10.1021/acs.jmedchem.0c01533

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Article

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.

Journal of medicinal chemistry - 25 Feb 2021

Mallart Sergio, Ingenito Raffaele, Bianchi Elisabetta, Bresciani Alberto, Esposito Simone, Gallo Mariana, Magotti Paola, Monteagudo Edith, Orsatti Laura, Roversi Daniela, Santoprete Alessia, Tucci Federica, Veneziano Maria, Bartsch Régine, Boehm Claudius, Brasseur Denis, Bruneau Patricia, Corbier Alain, Froissant Jacques, Gauzy-Lazo Laurence, Gervat Vincent, Marguet Frank, Menguy Isabelle, Minoletti Claire, Nicolas Marie-Françoise, Pasquier Olivier, Poirier Bruno, Raux Alexandre, Riva Laurence, Janiak Philip, Strobel Hartmut, Duclos Olivier, Illiano Stephane

Abstract excerpt

The insulin-like peptide human relaxin-2 was identified as a hormone that, among other biological functions, mediates the hemodynamic changes occurring during pregnancy. Recombinant relaxin-2 (serelaxin) has shown beneficial effects in acute heart failure, but its full therapeutic potential has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care...

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PMID: 33555858
DOI: 10.1021/acs.jmedchem.0c01533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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