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Article

Development of a selective agonist for relaxin family peptide receptor 3.

Scientific reports - 12 Jun 2017

Wei Dian, Hu Meng-Jun, Shao Xiao-Xia, Wang Jia-Hui, Nie Wei-Han, Liu Ya-Li, Xu Zeng-Guang, Guo Zhan-Yun

Abstract excerpt

Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1-4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present. A previously designed chimeric R3/I5 peptide, consisting of the B-chain of relaxin-3 and the A-chain of INSL5, displays equal activity towards the homologous RXFP3 and RXFP4. To increase its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28607363
DOI: 10.1038/s41598-017-03465-7
PMCID: PMC5468247

Genes

RXFP3
RXFP4
INSL5
RXFP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Development of a selective agonist for relaxin family peptide receptor 3.PMID 28607363Read ↗

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3Semantic proximity Read ↗

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Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).Semantic proximity Read ↗

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