Article
GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome.
Experimental hematology - 1 Jul 2016
Botezatu Lacramioara, Michel Lars C, Makishima Hideki, Schroeder Thomas, Germing Ulrich, Haas Rainer, van der Reijden Bert, Marneth Anne E, Bergevoet Saskia M, Jansen Joop H, Przychodzen Bartlomiej, Wlodarski Marcin, Niemeyer Charlotte, Platzbecker Uwe, Ehninger Gerhard, Unnikrishnan Ashwin, Beck Dominik, Pimanda John, Hellström-Lindberg Eva, Malcovati Luca, Boultwood Jacqueline, Pellagatti Andrea, Papaemmanuil Elli, Le Coutre Philipp, Kaeda Jaspal, Opalka Bertram, Möröy Tarik, Dührsen Ulrich, Maciejewski Jaroslaw, Khandanpour Cyrus
Abstract excerpt
Inherited gene variants play an important role in malignant diseases. The transcriptional repressor growth factor independence 1 (GFI1) regulates hematopoietic stem cell (HSC) self-renewal and differentiation. A single-nucleotide polymorphism of GFI1 (rs34631763) generates a protein with an asparagine (N) instead of a serine (S) at position 36 (GFI1(36N)) and has a prevalence of 3%-5% among Caucasians. Because...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.