Article
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
Blood - 25 Mar 2010
Khandanpour Cyrus, Thiede Christian, Valk Peter J M, Sharif-Askari Ehssan, Nückel Holger, Lohmann Dietmar, Horsthemke Bernhard, Siffert Winfried, Neubauer Andreas, Grzeschik Karl-Heinz, Bloomfield Clara D, Marcucci Guido, Maharry Kati, Slovak Marilyn L, van der Reijden Bert A, Jansen Joop H, Schackert Hans K, Afshar Khashayar, Schnittger Susanne, Peeters Justine K, Kroschinsky Frank, Ehninger Gerhard, Lowenberg Bob, Dührsen Ulrich, Möröy Tarik
Abstract excerpt
The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the mouse, Gfi1 deficiency causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome. We report here that a variant allele of GFI1 (GFI1(36N)) is associated with acute myeloid leukemia (AML) in white subjects with an odds ratio of 1.6 (P < 8 x 10(-5))....
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