Article
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Blood - 8 Nov 2012
Khandanpour Cyrus, Krongold Joseph, Schütte Judith, Bouwman Frederique, Vassen Lothar, Gaudreau Marie-Claude, Chen Riyan, Calero-Nieto Fernando J, Diamanti Evangelia, Hannah Rebecca, Meyer Sara E, Grimes H Leighton, van der Reijden Bert A, Jansen Joop H, Patel Chandrashekhar V, Peeters Justine K, Löwenberg Bob, Dührsen Ulrich, Göttgens Bertie, Möröy Tarik
Abstract excerpt
The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 3%-7% of whites and increases the risk for acute myeloid leukemia (AML) by 60%. We show here that GFI136N, in contrast to GFI136S, lacks the ability to bind to the Gfi1 target gene that encodes the leukemia-associated transcription factor Hoxa9 and fails to initiate histone modifications that...
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