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Article

LSD1 inhibition modulates transcription factor networks in myeloid malignancies

10 Mar 2023

Abstract excerpt

Acute Myeloid Leukemia (AML) is a type of cancer of the blood system that is characterized by an accumulation of immature hematopoietic cells in the bone marrow and blood. Its pathogenesis is characterized by an increase in self-renewal and block in differentiation in hematopoietic stem and progenitor cells. Underlying its pathogenesis is the acquisition of mutations in these cells. As there are many different...

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PMID: 36969082
DOI: 10.3389/fonc.2023.1149754

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