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Article

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

27 Sept 2023

Abstract excerpt

ABSTRACT: Growth factor independence 1 (GFI1) is a DNA-binding transcription factor and a key regulator of hematopoiesis. GFI1-36N is a germ line variant, causing a change of serine (S) to asparagine (N) at position 36. We previously reported that the GFI1-36N allele has a prevalence of 10% to 15% among patients with acute myeloid leukemia (AML) and 5% to 7% among healthy Caucasians and promotes the development...

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Share to Acute Myeloid Leukemia Research
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PMID: 37756525
DOI: 10.1182/blood.2022015752

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