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Article

Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification.

Oncogene - 13 Oct 2016

Barbelanne M, Chiu A, Qian J, Tsang W Y

Abstract excerpt

Centrioles are critical for many cellular processes including cell division and cilia assembly. The number of centrioles within a cell is under strict control, and deregulation of centriole copy number is a hallmark of cancer. The molecular mechanisms that halt centriole amplification have not been fully elucidated. Here, we found that centrosomal protein of 76 kDa (Cep76), previously shown to restrain centriole...

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Source

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Identifiers

PMID: 27065328
DOI: 10.1038/onc.2016.74
PMCID: PMC5125818

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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