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Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis

10 Mar 2025

Abstract excerpt

Accurate procentriole formation is critical for centriole duplication. However, the holistic transcriptional regulatory mechanisms underlying this process remain elusive. Here, we show that KAT7 crotonylation, facilitated by the crotonyltransferase hMOF, competes against its acetylation regulated by the deacetylase HDAC2 at the K432 residue upon DNA damage stimulation. This competition diminishes its histone...

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PMID: 40064919
DOI: 10.1038/s41467-025-57546-7

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