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Article

PLK4: a link between centriole biogenesis and cancer

24 Nov 2017

Abstract excerpt

INTRODUCTION: Polo like kinase (PLK) is known to play a pivotal role in various cell cycle processes to perpetuate proper division and growth of the cells. Polo like kinase-4 (PLK4) is one such kinase that appears in low abundance and plays a well-characterized role in centriole duplication. PLK4 deregulation (i.e. both overexpression and depletion of PLK4), leads to altered mitotic fidelity and thereby triggers...

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PMID: 29171762
DOI: 10.1080/14728222.2018.1410140

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