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Article

GCP6 is a substrate of Plk4 and required for centriole duplication

15 Jan 2012

Abstract excerpt

Centriole duplication occurs once per cell cycle and requires Plk4, a member of the Polo-like kinase family. A key component of the centrosome is the γ-tubulin ring complex (γ-TuRC) that nucleates microtubules. GCP6 is a member of the γ-TuRC, but its role in human cells and the regulation of its functions remain unclear. Here we report that depletion of human GCP6 prevents assembly of the γ-TuRC and induces a...

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PMID: 22302995
DOI: 10.1242/jcs.093930

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Related research

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GCP6 is a substrate of Plk4 and required for centriole duplicationPMID 22302995Read ↗

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