Article

A dual mechanism of sensitivity to PLK4 inhibition by RP-1664 in neuroblastoma

2025-02-17

Abstract excerpt

<h4>ABSTRACT</h4> A novel therapeutic strategy was recently proposed for high-risk neuroblastoma carrying copy number gain of the TRIM37 gene: centriole loss upon inhibition of polo-like kinase 4 (PLK4), while tolerated by normal cells, induces aberrant mitotic spindle formation and p53-dependent cell death in TRIM37 -overexpressing cells. Interestingly, while full PLK4 inhibition causes centriole loss, partial...

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Literature Corpus work: 220f1351-ca90-5b72-9620-d3eb980c916f
DOI: 10.1101/2025.02.15.638336

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