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Article

CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes

31 Jan 2011

Abstract excerpt

BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis. METHODOLOGY/PRINCIPAL FINDINGS: In addition to these previously described roles, our study shows that CDK11(p58) inhibition induces a failure in the centriole duplication process in different human cell lines. We propose that this...

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PMID: 21297952
DOI: 10.1371/journal.pone.0014600

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Related research

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Research trail→

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CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic CentrosomesPMID 21297952Read ↗

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The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.Semantic proximity Read ↗

CP110, a Cell Cycle-Dependent CDK Substrate, Regulates Centrosome Duplication in Human CellsSemantic proximity Read ↗

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)Semantic proximity Read ↗

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.Semantic proximity Read ↗

Binding of CEP152 to PLK4 stimulates kinase activity to promote centriole assemblySemantic proximity Read ↗

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.Semantic proximity Read ↗

PLK4: a link between centriole biogenesis and cancerSemantic proximity Read ↗

GCP6 is a substrate of Plk4 and required for centriole duplicationSemantic proximity Read ↗

Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.Semantic proximity Read ↗

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