Article
A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins.
The Journal of biological chemistry - 3 Jun 2016
Pfeiffer Anett, Stephanowitz Heike, Krause Eberhard, Volkwein Corinna, Hirsch Christian, Jarosch Ernst, Sommer Thomas
Abstract excerpt
A quality control system in the endoplasmic reticulum (ER) efficiently discriminates polypeptides that are in the process of productive folding from conformers that are trapped in an aberrant state. Only the latter are transported into the cytoplasm and degraded in a process termed ER-associated protein degradation (ERAD). In the ER, an enzymatic cascade generates a specific N-glycan structure of seven mannosyl...
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