Article

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> The SEL1L-HRD1 complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD), a critical pathway that clears misfolded proteins to maintain ER proteostasis. However, the molecular organization and pathogenic mechanisms of mammalian ERAD have remained elusive. Here, we report the first cryo-EM structure of the core mammalian ERAD complex, comprising the...

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Literature Corpus work: b837f910-59b5-5852-89cb-80215ce8382c
DOI: 10.1101/2025.06.13.659592

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