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Article

ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.

Science (New York, N.Y.) - 25 Jul 2008

Ushioda Ryo, Hoseki Jun, Araki Kazutaka, Jansen Gregor, Thomas David Y, Nagata Kazuhiro

Abstract excerpt

Membrane and secretory proteins cotranslationally enter and are folded in the endoplasmic reticulum (ER). Misfolded or unassembled proteins are discarded by a process known as ER-associated degradation (ERAD), which involves their retrotranslocation into the cytosol. ERAD substrates frequently contain disulfide bonds that must be cleaved before their retrotranslocation. Here, we found that an ER-resident protein...

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Identifiers

PMID: 18653895
DOI: 10.1126/science.1159293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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