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Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality control

22 Aug 2025

Abstract excerpt

Misfolded proteins can be toxic to cells, and their accumulation is a hallmark of diseases such as neurodegeneration. Normally, protein homeostasis is maintained by quality control processes that eliminate misfolded proteins. In the endoplasmic reticulum (ER), misfolded proteins are eliminated through endoplasmic reticulum-associated degradation (ERAD). This process is mediated by ubiquitin ligase complexes that...

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PMID: 40848517
DOI: 10.1016/j.ceb.2025.102580

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