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Article

Yeast N-glycanase distinguishes between native and non-native glycoproteins.

EMBO reports - 1 Feb 2004

Hirsch Christian, Misaghi Shahram, Blom Daniël, Pacold Michael E, Ploegh Hidde L

Abstract excerpt

N-glycanase from Saccharomyces cerevisiae (Png1) preferentially removes N-glycans from misfolded proteins. The ability of Png1 to distinguish between folded and misfolded glycoproteins is reminiscent of substrate recognition by UDP-glucose glycoprotein glucosyl transferase, an enzyme that possesses this trait. The only known in vivo substrates of Png1 are aberrant glycoproteins that originate in the endoplasmic...

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Source

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Identifiers

PMID: 14726951
DOI: 10.1038/sj.embor.7400066
PMCID: PMC1298977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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