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Article

Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.

Molecular biology of the cell - 1 Dec 2012

Tyler Ryan E, Pearce Margaret M P, Shaler Thomas A, Olzmann James A, Greenblatt Ethan J, Kopito Ron R

Abstract excerpt

Degradation of folding- or assembly-defective proteins by the endoplasmic reticulum-associated degradation (ERAD) ubiquitin ligase, Hrd1, is facilitated by a process that involves recognition of demannosylated N-glycans by the lectin OS-9/XTP3-B via the adaptor protein SEL1L. Most of our knowledge of the machinery that commits proteins to this fate in metazoans comes from studies of overexpressed mutant proteins...

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Identifiers

PMID: 23097496
DOI: 10.1091/mbc.E12-06-0428
PMCID: PMC3521676

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Source receipt: pubmed, retrieved 7 Sept 2026.

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