Article
Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.
Pharmacogenetics and genomics - 1 Oct 2013
Donnelly Louise A, van Zuydam Natalie R, Zhou Kaixin, Tavendale Roger, Carr Fiona, Maitland-van der Zee Anke H, Leusink Maarten, de Boer Anthonius, Doevendans Pieter A, Asselbergs Folkert W, Morris Andrew D, Pearson Ewan R, Klungel Olaf H, Doney Alex S F, Palmer Colin N A
Abstract excerpt
OBJECTIVES: The LPA single-nucleotide polymorphism rs10455872 has been associated with low-density lipoprotein cholesterol (LDLc) lowering response to statins in several randomized control trials (RCTs) and is a known coronary artery disease (CAD) marker. However, it is unclear what residual risk of CAD this marker may have during statin treatment. METHODS: Using electronic medical records linked to the GoDARTS...
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