Article
Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.
Pharmacogenomics - 1 Oct 2016
Smit Roelof Aj, Postmus Iris, Trompet Stella, Barnes Michael R, Warren Helen, Arsenault Benoit J, Chasman Daniel I, Cupples L Adrienne, Hitman Graham A, Krauss Ronald M, Li Xiaohui, Psaty Bruce M, Stein Charles M, Rotter Jerome I, Jukema J Wouter
Abstract excerpt
AIMS: To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response. METHODS: We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic...
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