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Article

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy.

Nature communications - 5 Apr 2016

Findlay John M, Castro-Giner Francesc, Makino Seiko, Rayner Emily, Kartsonaki Christiana, Cross William, Kovac Michal, Ulahannan Danny, Palles Claire, Gillies Richard S, MacGregor Thomas P, Church David, Maynard Nicholas D, Buffa Francesca, Cazier Jean-Baptiste, Graham Trevor A, Wang Lai-Mun, Sharma Ricky A, Middleton Mark, Tomlinson Ian

Abstract excerpt

How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with higher mutation burden pre-treatment. Some poor responders pass through bottlenecks, but re-grow by the time of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27045317
DOI: 10.1038/ncomms11111
PMCID: PMC4822033

Genes

CCND2
TAF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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