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Article

Whole genome sequencing in oesophageal adenocarcinoma unmasks potential precision therapies.

BMC cancer - 25 May 2026

Sharma Sowmya, Wong Ho Yi, Johnston Rebecca L, Koufariotis Lambros T, Wood Scott, Hollway Georgina, Aoude Lauren G, Davidson Aimee L, Pearson John V, Lin Frank P, Barbour Andrew P, Waddell Nicola

Abstract excerpt

BACKGROUND: Oesophageal adenocarcinoma (OAC) incidence continues to rise in developed countries. Despite advances in deciphering cancer genomes and oncogenic pathways, precision therapies for OAC remain limited. An expansion of precision therapy repertoire in OAC is urgently required. METHODS: We assembled 109 actionable and/or potentially actionable genes based on pan-cancer drug information from open-source...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42186016
DOI: 10.1186/s12885-026-16044-9
PMCID: PMC13386782

Genes

KRAS
PTEN
TP53
APC
ARID1A
BRCA1
BRCA2
CCNE1
CD24
CDKN2A
EGFR
ERBB2
MDM2
MET
PIK3CA
PVR
SLC3A2
SMARCB1
TSC2
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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