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Article

A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.

Genome research - 1 Jun 2017

Noorani Ayesha, Bornschein Jan, Lynch Andy G, Secrier Maria, Achilleos Achilleas, Eldridge Matthew, Bower Lawrence, Weaver Jamie M J, Crawte Jason, Ong Chin-Ann, Shannon Nicholas, MacRae Shona, Grehan Nicola, Nutzinger Barbara, O'Donovan Maria, Hardwick Richard, Tavaré Simon, Fitzgerald Rebecca C

Abstract excerpt

The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, chemoresistant tumor for which the availability and size of pretreatment endoscopic samples are limiting. This study compares whole-genome sequencing data obtained from chemo-naive and chemo-treated...

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Topics

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Share to Adenocarcinoma
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Esophageal Neoplasms

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Share to Neoadjuvant Therapy

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Source

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Identifiers

PMID: 28465312
DOI: 10.1101/gr.214296.116
PMCID: PMC5453324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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