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Article

Genome-wide and panel-based cell-free DNA characterization of patients with resectable esophageal adenocarcinoma.

The Journal of pathology - 1 Nov 2023

van den Ende Tom, van der Pol Ymke, Creemers Aafke, Moldovan Norbert, Boers Dries, van Berge Henegouwen Mark I, Hulshof Maarten Ccm, Cillessen Saskia Agm, van Grieken Nicole Ct, Pegtel D Michiel, Derks Sarah, Bijlsma Maarten F, Mouliere Florent, van Laarhoven Hanneke Wm

Abstract excerpt

Circulating tumor DNA (ctDNA) holds promise in resectable esophageal adenocarcinoma (EAC) to predict patient outcome but is not yet sensitive enough to be clinically applicable. Our aim was to combine ctDNA mutation data with shallow whole-genome sequencing (sWGS)-derived copy number tumor fraction estimates (ichorCNA) to improve pathological response and survival prediction in EAC. In total, 111 stage II/III EAC...

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Source

Identifiers

PMID: 37615198
DOI: 10.1002/path.6175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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