Article
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.
Cancer research - 15 May 2016
Satoh Hironori, Moriguchi Takashi, Saigusa Daisuke, Baird Liam, Yu Lei, Rokutan Hirofumi, Igarashi Keiko, Ebina Masahito, Shibata Tatsuhiro, Yamamoto Masayuki
Abstract excerpt
Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations in Nrf2 also confer malignant characters to human cells by activating antioxidative/detoxifying enzymes and metabolic reprogramming. In this study, we examined how these contradictory activities of Nrf2, cancer chemoprevention and cancer cell growth enhancement, can be reconciled in an established mouse model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.