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Article

Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels.

Carcinogenesis - 30 Aug 2022

Satoh Hironori, Arai Yasuhito, Furukawa Eisaku, Moriguchi Takashi, Hama Natsuko, Urushidate Tomoko, Totoki Yasushi, Kato Mamoru, Ohe Yuichiro, Yamamoto Masayuki, Shibata Tatsuhiro

Abstract excerpt

The transcription factor Nrf2 plays a crucial role in the anti-oxidative stress response, protection of DNA from injury and DNA repair mechanisms. Nrf2 activity reduces cancer initiation, but how Nrf2 affects whole-genome alterations upon carcinogenic stimulus remains unexplored. Although recent genome-wide analysis using next-generation sequencing revealed landscapes of nucleotide mutations and copy number...

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PMID: 35561328
DOI: 10.1093/carcin/bgac041

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