Article

Distinct Roles for the Thioredoxin and Glutathione Antioxidant Systems in Nrf2-Mediated Lung Tumor Initiation and Progression

2024-08-20

Abstract excerpt

<h4> Abstract </h4> Redox regulators are emerging as critical mediators of lung tumorigenesis. NRF2 and its negative regulator KEAP1 are commonly mutated in human lung cancers, leading to NRF2 accumulation and constitutive expression of NRF2 target genes, many of which are at the interface between antioxidant function and anabolic processes that support cellular proliferation. Nrf2 activation promotes lung tumor...

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Literature Corpus work: dd62b92a-cab4-5c19-9d7c-92b65bb49cf8
DOI: 10.1101/2024.08.20.608800

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