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Article

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis.

Cancer research - 1 Jul 2013

Satoh Hironori, Moriguchi Takashi, Takai Jun, Ebina Masahito, Yamamoto Masayuki

Abstract excerpt

Nrf2 (Nfe2l2) governs cellular defenses against oxidative and electrophilic stresses and protects against chemical carcinogenesis. However, many cancers have been found to accumulate NRF2 protein, raising questions of precisely how Nrf2 contributes to carcinogenesis. In this report, we explored such questions in an established urethane-induced multistep model of lung carcinogenesis. Consistent with earlier...

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PMID: 23610445
DOI: 10.1158/0008-5472.CAN-12-4499

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