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Article

Keap1 deletion accelerates mutant K-ras/p53-driven cholangiocarcinoma.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2020

Nabeshima Tatsuhide, Hamada Shin, Taguchi Keiko, Tanaka Yu, Matsumoto Ryotaro, Yamamoto Masayuki, Masamune Atsushi

Abstract excerpt

The activation of the Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) pathway contributes to cancer progression in addition to oxidative stress responses. Loss-of-function Keap1 mutations were reported to activate Nrf2, leading to cancer progression. We examined the effects of Keap1 deletion in a cholangiocarcinoma mouse model using a mutant K-ras/p53 mouse. Introduction of the Keap1...

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Identifiers

PMID: 31961719
DOI: 10.1152/ajpgi.00296.2019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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