Article
Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia.
The pharmacogenomics journal - 1 Jun 2017
Alachkar H, Fulton N, Sanford B, Malnassy G, Mutonga M, Larson R A, Bloomfield C D, Marcucci G, Nakamura Y, Stock W
Abstract excerpt
Asparaginase, which depletes asparagine and glutamine, activates amino-acid stress response. Oxidative stress mediated by excessive reactive oxygen species (ROS) causes enhanced mitochondrial permeabilization and subsequent cell apoptosis and is considered as a plausible mechanism for drug-induced hepatotoxicity, a common toxicity of asparaginase in adults with acute lymphoblastic leukemia (ALL). Studies...
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