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Article

Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.

Pediatric hematology and oncology - 1 Aug 2010

Horinouchi Masanori, Yagi Mariko, Imanishi Hiroyuki, Mori Takeshi, Yanai Tomoko, Hayakawa Akira, Takeshima Yasuhiro, Hijioka Michiyo, Okamura Noboru, Sakaeda Toshiyuki, Matsuo Masafumi, Okumura Katsuhiko, Nakamura Tsutomu

Abstract excerpt

The objective of this study was to identify novel pharmacogenetic determinants of treatment-related hepatotoxicity during the maintenance phase in children with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL). Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and...

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Share to Chemical and Drug Induced Liver Injury
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Association Studies

Share to GTPase-Activating Proteins

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 20670164
DOI: 10.3109/08880011003739422

Genes

ARHGAP24
GSTM1
GSTP1
GSTT1
KCNIP4
MTHFR
RASGRP1
RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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