Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia.

doi:10.1016/j.biopha.2022.113000

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Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jun 2022

Wu Sharon, Wang Mengxi, Alqahtani Amani, Lou Mimi, Stock Wendy, Bhojwani Deepa, Alachkar Houda

Abstract excerpt

Asparaginase is an integral component of acute lymphoblastic leukemia (ALL)3 treatment. Hepatotoxicity related to asparaginase is one of the most common treatment-related toxicities in ALL therapy. Hispanic children are at higher risk of developing ALL, and toxicities from ALL therapy. The rs4880 variant in the superoxide dismutase 2 (SOD2)4 gene, a critical mitochondrial enzyme that protects cells against...

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Identifiers

PMID: 35658244
DOI: 10.1016/j.biopha.2022.113000
PMCID: PMC9450009

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Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia.PMID 35658244Read ↗

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