Back to search

Article

Polygenic risk score-assessment of drug induced hepatotoxicity in high-risk acute lymphoblastic leukemia

2023-10-18

Abstract excerpt

<h4>Introduction: </h4> Genetic variations are associated with an increasing risk of asparaginase hepatotoxicity in acute lymphoblastic leukemia (ALL). The polygenetic risk assessment (PRS) of the representative genetic variants can contribute to increasing risk prediction to personalize the treatment. Herein, we estimated the single variants-phenotype and polygenetic-phenotype analysis. <h4>Materials: </h4> and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c1d84028-33d0-5262-9b9b-356d6fa1159f
DOI
10.21203/rs.3.rs-3445264/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Polygenic risk score-assessment of drug induced hepatotoxicity in high-risk acute lymphoblastic leukemiaDOI 10.21203/rs.3.rs-3445264/v1
Polygenic Pharmacogenomic Markers as Predictors of Toxicity Phenotypes in the Treatment of Acute Lymphoblastic Leukemia: A Single-Center Study.Semantic proximity
Pharmacogenetics of induction therapy-related toxicities in childhood acute lymphoblastic leukemia patients treated with UKALL 2003 protocol.Semantic proximity
Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.Semantic proximity
Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in LatinosSemantic proximity
Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia.Semantic proximity
Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review)Semantic proximity
Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia.Semantic proximity
The characteristics and risk factors of asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemiaSemantic proximity
A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population.Semantic proximity
The role of genetic polymorphism in predictive model of ATDHSemantic proximity
Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexateSemantic proximity
Implications of ACMG guidelines to identify high-risk acute lymphoblastic leukemia patients with hereditary cancer susceptibility syndromes (HCSS) in a highly consanguineous population.Semantic proximity
Select a neighboring publication to make it the new centre.